ABSTRACT
Objective: To observe the effect of Weixikang apozema on growth factor of acetic acid gastric ulcer rats.Methods: The rats were divided into blank control group(abbreviated as blank group),model group,ranitidine group,Weixikang low dosage group(abbreviated as low dosage group) and Weixikang high dosage group(abbreviated as high dosage group) at random,each group has 8 rats.The content of epidermal growth factor(EGF) and transforming growth factor-?(TGF-?) were measured with radioimmunoassay.The protein expression of EGF,TGF? and EGFR were measured with immunohistochemical method.Results: The content of EGF and TGF-? and the protein expression of EGF,TGF-? and EGFR in low dosage group and high dosage group have increased(P
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Chinese drugs of Jianpi Huayu (JPHY, strengthening Pi and dissolving stasis) on healing quality of gastric ulcer and its mechanism.</p><p><b>METHODS</b>The gastric ulcer model was established by subserous injection of ethanoic acid in rats. Rats were randomly divided into 4 groups, the blank group, the model group, the ranitidine (RT) group and the JPHY group. Quantity of regenerative mucosa of healed gastric ulcer was determined using HE stain, epidermal growth factor (EGF) content in serum and stomach mucosa was detected by RIA and epidermal growth factor receptor (EGFR) protein expression was determined by immunohistochemistry.</p><p><b>RESULTS</b>Thickness of regenerated mucosa in the CHM group was higher than that in the model group and the RT group (P<0.05 or P<0.01); EGF content in mucosa in the JPHY group and the RT group was higher than that in the model group (P<0.01) and EGFR protein expression in the JPHY group was higher than that in the model group (P<0.05).</p><p><b>CONCLUSION</b>JPHY could improve the proliferation of epithelial cells, inhibit gastric acid, improve microcirculation of gastric mucosa through the mediation of EGFR, so as to elevate the healing quality of gastric ulcer, display its anti-ulcer action.</p>
Subject(s)
Animals , Male , Rats , Acetic Acid , Anti-Ulcer Agents , Pharmacology , Drugs, Chinese Herbal , Pharmacology , Epidermal Growth Factor , Metabolism , Gastric Mucosa , Metabolism , Pathology , Random Allocation , Rats, Wistar , ErbB Receptors , Metabolism , Stomach UlcerABSTRACT
Objective To observe the effect of herbal medicines with the function of replenish qi and essence for the immune func- tion of patients after mammary cancer operation.Methods The 115 patients of mammary cancer after modified radical operation were randomized into treatment group and control group.The treatment group began to take the decoction of herbal medicines from 7 days before and from the 3rd day after operation.The control group had the same treatment but without taking herbal medicines.The im- mune indices of both groups were tested on the day 7 days before,one day and 14 days after operation respectively.Results In the treatment group,IgA,IgG,IgM were remarkably increased in comparison with the control group 14 days after operation;with the herbal treatment for 2 weeks,CD_4,CD_4/CD_8,IL-2 rised remarkably(P